Heart Attack is more inheritable than stroke

In a study published yesterday by Circulation: Cardiovascular Genetics, TheHeart.org discusses the genetic link between inherited Myocardial Infarction (MI or heart attack) and inherited stroke. While the link between MI and your parents is there, it is not an overwhelming factor (although, in my particular case, it seems to be the only factor we can determine). In stroke, it seems, it is even less of a factor.
In the study, they looked at histories of 906 people with Acute Coronary Syndrome (ACS) and at 1015 people with histories of TIA or stroke. The findings were significantly different:
In the patients with TIA or stroke:
  • 21.3% had one parent with stroke
  • 2.1% had two parents with stroke
  • 8.1% had at least one sibling with stroke
  • 1.4% had at least two siblings with stroke
In those with ACS, the results showed significantly more inheritance/genetics at work:
  • 30.6% had one parent with MI
  • 5.2% had two parents with MI
  • 21.1% had at least one sibling with MI
  • 7.1% had at least two siblings with MI
In the article, they run through the math, but here's the bottom line - if you compare people with stroke with people with heart disease, the folks with heart disease were over 5 times more likely to have two or more siblings with the same condition. They were 2.6 times more likely to have at least one sibling with ACS.
This means that heart disease has a moderate inherited, genetic factor. The numbers are so low for stroke inheritability that researchers believe there is a much smaller link - the factors that determine stroke seem to be much more environmental. This reinforces familial history when looking at MI risk - a very easy question to answer - it costs nothing and involves no tests.
So if one or more of your siblings or parents has heart disease - look for it in your own health!

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New stroke drug more than doubles time...

A naturally occurring substance which is produced by the body as a stress response to stroke, alpha-B-crystallin, works to absorb inflammation molecules in the brain to reduce damage. When more of this substance is introduced up to 12 hours after a stroke, it reduces the size of the resulting brain lesions. Experiments were performed on alpha-B-crystallin deprived genetically deprived mice, which showed much improved outcomes for the treated mice versus their control group.

The stuff we use now, TPA, must be administered withing 4.5 hours of the stroke.

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Heat Stroke!

This has absolutely nothing to do with stroke, but shares the name. And it's that time of the year, so I thought this is information everyone could use...

What is heat stroke?

Heat stroke is defined as having a body temperature of greater than 40.6 degrees Celcius (105.1 degrees F). It's caused by the inability of the body to self-regulate it's core temperature due to heat and humidity. The body cannot get rid of all this excess heat - which it would normally do by sweating. This is why excessive humidity is a strong correlating factor. Predisposition to heat stroke can happen with the use of caffeine, stimulants, medications and alcohol - they all cause dehydration and inhibit cooling. Heat stroke also happens with young, fit people under exertion in the heat - think army recruits or football players.
Symptoms of heat stroke
Heat stroke symptoms include confusion and lack of sweating - confusion because your brain heats up and it starts behaving strangely, and lack of sweating because your body can't perspire enough to keep your body temperature down, so it stops altogether. Then things cascade rapidly.
Prevention
Prevention of heat stroke is sometimes easier said than done. Primarily, avoid dehydration and overheating. Wear light colored clothing that will allow your perspiration to evaporate (and cool your body). Wide brimmed, light colored, vented hats don't allow direct sunlight to hit your head and neck, but will allow sweat from your head to evaporate. Remember that as humidity goes up, your body has a harder time regulating your internal heat, so it needs all the help it can get. Make sure that the clothing you are wearing both blocks harmful UV from the sun, and doesn't absorb the heat (so, light colored), but also that it allows perspiration to evaporate - chose fabrics like cotton over artificial, non-breathing, plastics.
Avoiding strenuous exercise during daylight hours is another practical tip - heat exhaustion is common among athletes. Stay out of enclosed spaces like cars - they can reach up to 200 degrees (F) very quickly in the right conditions. Children and pets are especially prone to quickly succumbing to heat stroke (and death) in cars baking in the warm sunlight. We hear about these instances in the news every summer. Dogs and cats cannot sweat through their skin (fur), so they are much more apt to succumb to heat stroke than people. Leave your pets at home!
It's also very important to remain hydrated. Thirst is not a good measure of hydration. Rather, the color of your urine is ... make sure it remains "straw colored" or even clear. Drink often, and maintain that color! There's come controversy whether it's better to drink sports drinks or water, as when you sweat you lose valuable sodium (which sports drinks replace). Low sodium can cause heart attacks, so maybe 50/50 is the right answer for a long day in the sun.
Treatment
The treatment for heat stroke is to quickly lower the body temperature and resuscitate (if they're not breathing) using CPR. Rapid lowering involves moving the person indoors (or into the shade if indoors is unavailable). Remove their clothing to promote "passive" cooling ... a fan or air conditioner can help. Active cooling can involve a cool (not cold) bath or a hypothermia vest. Applying cool towels to the head, neck, groin and torso can also help. 
Re-hydration is very important too. If the patient can drink - get them water immediately. If they're unconscious, you'll have to have an IV started (bottom line - get emergency help). Cooling and re-hydrating a body can get complicated (you don't want to prevent sweating or promote heating). But those first few minutes can save a life - do what you can before the emergency team shows up!

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Optimism - go figure

A recent study reported in Stroke: Journal of the American Heart Association has found that those people who are optimistic about their outcomes (better days to come - the worst is behind them) actually do experience better recovery and results after their stroke. The brain is a funny thing, as we know from experiments with placebos. Researchers believe there may be a biological difference in the optimists versus the pessimists of this group - they not only believe they will get better, but their body behaves that way as well.

The study looked at over 6000 people over age 50 and rated their optimism levels on a 16-point scale. Each single-point increase in the scale correlated to a 9 percent decrease in their stroke risk over a two year period (note that "negative outcome" was determined to be another stroke). The findings of this study - specific to stroke - are similar to results obtained when heart patients are measured about a brighter future.

There may be a cause/effect issue here, as people that are optimistic about their future health with ordinarily take steps to ensure good health (eating better, exercise, taking their meds) - while people depressed about their situation are more likely to have things deteriorate (sit around, skip meds, eat crap).

The bottom line for me - thinking positively about the future is not only easier, it's healthier!


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